Home Chemistry Heterocyclic Building Blocks Benzimidazoles 2-Benzyl-1H-Benzo[D]Imidazole
Acylation: You can react it with an acylating agent (e.g., acyl chlorides or anhydrides) to introduce an acyl group (R-CO-) onto the nitrogen atom, forming an N-acylated product.
Amination: You can perform amination reactions to introduce various amino groups onto the imidazole nitrogen atom.
Alkylation: You can alkylate the imidazole nitrogen atom with alkyl halides or similar compounds to introduce alkyl groups.
Aldol Condensation: If it contains an active hydrogen, it can participate in aldol condensation reactions.
Reduction: You can reduce the imine or ketone functional groups in the molecule using reducing agents like sodium borohydride (NaBH4) to obtain the corresponding amine or alcohol derivatives.
Substitution Reactions: You can perform substitution reactions, such as nucleophilic aromatic substitution (SNAr) reactions on the aromatic ring, where the benzyl group can be substituted by various nucleophiles.
Oxidation: Depending on the functional groups present, you can oxidize the compound using oxidizing agents.
Heterocyclization: It can participate in heterocyclization reactions to form fused or spirocyclic compounds, depending on the reaction conditions and reagents.
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2-(4-Chlorobenzyl)-6-nitro-1H-benzo[d]imidazole
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2-(2,4-Dichlorobenzyl)-1H-benzo[d]imidazole
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2-(3,4-Dichlorobenzyl)-1H-benzo[d]imidazole
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2-[(4-Methoxyphenyl)methyl]-1H-1,3-benzodiazole
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